Endocrine Abstracts

Introduction: Fine needle aspiration biopsy (FNAB) is the mainstay diagnostic procedure for evaluation of thyroid nodules, but it doesn’t permit to distinguish between benign and malignant follicular lesions (category IV in the Bethesda Cytopathology System). Some reports have suggested an association between increased serum levels of TSH and thyroid cancer. However, the specific relationship between TSH and malignancy has been scarcely studied in follicu...

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generate a pandemic disease around the world. It has been documented that diabetes mellitus (DM) acts as a risk factor among people hospitalized with coronavirus disease (COVID-19). The objective of this study is to test if DM may unfavorably influence the outcome of COVID-19.MethodsData from Hospital Universitario Central ...

Background: The treatment of neuroendocrine neoplasms (NENs) of higher grade remains a dilemma. In these patients the role of immunotherapy is still unclear and predictive biomarkers are an unmet need. Herein, we present a revised translational analysis of the NET001 and NET002 (NCT03278405, NCT03278379) clinical trials.Methods: Patients with advanced WHO G2-3 NENs who had a gastroenteropancreatic (GEP) or a bronchial primary (excluding typical carcinoid...

Background: Gastric neuroendocrine tumors (gNETs) are relatively uncommon. Represent up to 23% of all digestive neuroendocrine neoplasms. The majority are incidentally diagnosed from histology of ‘simple’ gastric polyps identified at endoscopy. There are 3 groups of gNETs: types 1, 2 and 3 with different pathogeneses, biological and clinical behaviors. It is worth mentioning that recent reports suggest a fourth type of gNETs1. Type I represents 75–80%...

Background: Lutetitum-177 (Lu-DOTATE) is an approved treatment regimen for patients with advanced neuroendocrine tumors (NETs). Improving patient experience is one of main goals of a cancer treatment plan. "Time-toxicity" describes the period that patients spend in doing administrative or medical procedures, including medical visits, scans, lab analyses, emergency room admissions, drug applications and hospitalizations. Modern therapies are usually approved after an im...

Hepatocellular carcinoma (HCC) is an aggressive tumour frequently associated to an underlying chronic liver disease. In this sense, metabolic dysfunction-associated steatotic liver disease (MASLD) is considered as a growing cause of HCC development. Considering the need of novel therapeutic approaches, and the promising data about targeting the tumour microenvironment in cancer, we performed quantitative proteomics on HCC samples to characterize the components and regulators o...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the main hepatic manifestation of obesity. MASLD was recently defined as liver steatosis in the presence of at least one cardiometabolic risk factor and reduced or absent alcohol intake. MASLD prevalence is rapidly increasing, thus becoming the fastest growing aetiology of the most common primary liver cancer, hepatocellular carcinoma (HCC), and the leading cause of liver transplantation in HCC patients. Curre...

Aim: The use of continuous subcutaneous insulin infusion (CSII) systems in type 1 diabetic patients (DM1) is progressively increasing, leading to an increase in cases in which its maintenance during hospitalization is considered. The objective of the study is to analyze the safety of glycemic control with CSII therapy during hospitalization in DM1 adults.Material and Methods: Retrospective observational study on a cohort of DM1 people hospitalized the la...

Background: Hypophosphatemic rickets are disabling conditions that negatively impact physical functioning, activities of daily living, mental health, social life, and leisure activities. The most common cause of Hypophosphatemic rickets is genetic factors, such as X-linked hypophosphatemia. The evaluation of the scientific application of familial hypophosphatemic rickets aids in understanding the research landscape, identifying opportunities for improvement, and promoting sign...

Aim: Illustrating a case series of two patients with levothyroxine malabsorption and suboptimal control of the thyroid profile who experienced a significant improvement after switching to liquid levothyroxine.Material and Methods: Case saries of two patients who were attended in monographic thyroid pathology consultations at Virgen Macarena University Hospital.Results: Case 1: a 46-year-old female patient who had multinodular goitr...